The Infant Development and Environment Study (PI Dr. Shanna Swan)
The Infant Development and Environment Study (TIDES) is a U.S. multi-center study (CA, WA, MN, NY) designed to examine how everyday chemicals in food, cosmetics, and household products may affect children’s health and development. https://icahn.mssm.edu/about/departments/environmental-public-health/research/tides
- In TIDES, we are studying the role of placental biomarkers in the association of prenatal phthalates and infant genital and brain-related outcomes. To do this, we are using measures of serum placental-fetal hormones abstracted from the medical record and also placental tissue samples collected from a subset of pregnancies at the TIDES UCSF site.
- Joint publication: PMID: 26200238
Conditions Affecting Neurocognitive Development and Learning in Early childhood (PI Dr. Fran Tylavsky)
CANDLE is an observational, longitudinal cohort research study of the development and ability to learn in children from birth to age four. A racially and economically diverse population of women were recruited in Shelby County, TN. The purpose of the CANDLE study is to identify factors during a pregnancy and baby’s first three years that impact the baby’s development and ability to learn.
- From CANDLE, we have received biospecimens from a pilot sample (N=50) to measure associations of prenatal phthalate exposures with circulating placental and maternal biomarkers, and infant cognition at 1 and 3 years of age.
- Joint Publication: PMID: 33928202
Understanding Pregnancy Signals and Infant Development (PIs Dr. Emily Barrett and Tom O’Connor)
UPSIDE is a birth cohort study in Rochester, NY. The purpose of this study is to learn about how the ways in which a mother’s daily environment and changing emotions may affect her baby’s development.
- In UPSIDE, we are measuring urinary phthalates and placental hormones in maternal circulation to evaluate the hypothesis that placental hCG mediates the association between prenatal phthalates and anogenital distance.
The Magee Childhood Trauma study is a longitudinal birth cohort study in Pittsburgh, PA to evaluate the effects of maternal adverse childhood events on stress biology in pregnancy, and brain development. (PIs Drs. Pathik Wadhwa, Hyagriv Simhan, Elissa Epel). This study is also part of the NIH ECHO program.
- In the Magee CT, we are measuring urinary phthalates and placental hormones in maternal circulation to evaluate the hypothesis that placental hCG mediates the association between prenatal phthalates and anogenital distance.
Magee Obstetric Maternal & Infant (MOMI) Database and Biobank is a resource created by MWRI to provide high quality biospecimens, linked to medical record data, sampled from a diverse population of women who are delivering at Magee Womens Hospital of UPMC.
- In the MOMI Biobank, we will measure urinary phthalate levels and placental biomarkers in serum and in placental tissue to evaluate hypotheses on the following exposures in the context of the 2020-2021 COVID-19 pandemic: food environment changes that affected phthalate levels, structural and individual level racial discrimination, SARS-CoV-2 exposure.
- We currently use MOMI Biobank samples in a course we teach entitled, ‘The Application of Molecular Biomarkers in Epidemiology.’